FACILE APPROACH FOR THE SYNTHESIS OF PYRIDAZINO[4,5-B]INDOL-4-ONE EXHIBITING ANTIPROLIFERATIVE ACTIVITY
DOI:
https://doi.org/10.53555/ans.v10i1.2475Keywords:
pyridazino[4,5-b]indol-4-one, carbonyldiimidazole, antiproliferative, HeLa cellsAbstract
Efficient and eco-friendly approach was made for the synthesis of a series of pyridazinone indoles from commercially available indole-3-carboxaldehyde and carbonyl diimidazole. The strategy was found to be efficient for an easy access of varieties of pyridazino[4,5-b]indol-4-ones under mild conditions. One pot carbonylation of indole nucleus and substituted hydrazine have been achieved with carbonyldiimidazole. A library of synthesized compounds 3a-p was evaluated for their potential towards antiproliferative behavior against HeLa cell lines. Among the series pyridazino[4,5-b]indol-4-ones, 3h, 3i, 3j and 3m come out to be promising candidates exhibiting moderate to high antiproliferative activities.
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